Not really. Most jobs have terrible WS's attached to their Mythic (or aren't melee jobs and the added effects are mostly just utility pieces that wont help that much) and don't have an easy way to keep AM3 up. Thus they have to use the terrible WS more often.
Ryunohige and Kogarasumaru are, by far as I can tell, the best 'powerhouse' Mythics in the game.
Drakesbane remains a good weapon skill despite the attack penalty and Spirit/Soul Jump are amazing TP gaining abilities. And Spirit Link to steal Wyvern TP. Gimped Meditate too if /SAM.
Samurai has ungimped Meditate and a crap ton of STP so they don't have to use Tachi: Rana too often.
WAR and DRK only have gimped Meditate and Absorb-TP to make up for it. King's Justice is mediocre and Insurgency is pretty terrible.
Oa2-3 Conquerer with Upheaval spam is boss. It's just hard to maintain AM3 constantly. Liberator isn't bad, it's just that insurgency sucks, but entropy certainly does not suck. Glanz does ok (but suffers from AM3 only working on 1 hand which is stupid), KKK does good, Ryu does great, but drg has jumps that can proc 2-3, so it has a nice advantage (as well as drg's SP2, and the fact that they added spirit/soul jumps). Kogara does great too.